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Simon Raffel will receive the Walter Schulz Prize for his discovery how misregulated breakdown of amino acids in leukemia stem cells promotes blood cancer. The two stem cell researchers have jointly demonstrated that the development of blood cells in the bone marrow follows very different paths from what scientists have assumed up to now.
Blood consists of a wide variety of cell types specialized on specific tasks: High quantities of these cells die every day and must immediately be resupplied by the blood-forming hematopoietic cells in the bone marrow. So far, thousands of cells had to be analyzed together in order to study hematopoiesis. The researchers developed a method to characterize the gene activity and the characteristics of thousands of individual stem cells separately.
Up to now, scientists have assumed that hematopoietic stem cells have to pass through defined development stages to develop into mature blood cells in a stepwise process.
However, Haas and Velten have now demonstrated that stem cells follow a continuous and gradual development process to mature into blood cells, without passing through the previously postulated defined intermediate stages. In addition, the two young researchers discovered a previously unnoticed heterogeneity in stem cells, suggesting that they commit to a specific differentiation path earlier than previously thought.
Haas demonstrated in mice that stem cell specialization important in order to be able to respond more quickly to stress such as in a viral infection. These results are also relevant in order to better comprehend how blood cancer develops. Velten and Haas are currently pursuing research on this.
Established inthe Walter Schulz Foundation annually gives a research award to young scientists who have attained an excellent accomplishment in tumor research. Raffel will receive the award on April 20 in Munich. Acute myeloid leukemia AML is an aggressive cancer of the blood that very
Sri Lanka Mädchen Kontakt recurs in the wake of successful initial treatment.
Therapy-resistant leukemia stem cells are the culprits for this. Raffel has Sri Lanka Mädchen Kontakt been able to show that an enzyme that is responsible for breaking down specific amino acids in food plays a key role in the development of this type of Sri Lanka Mädchen Kontakt. The enzyme, called BCAT1, is found at suspiciously high levels in leukemia stem cells.
These levels rise even higher during a cancer recurrence. Working in the group of Andreas Trumpp, Raffel discovered a surprising link between energy metabolism and the so-called "epigenetic code". These epigenetic labels determine whether particular genes are active or silent. The level of DNA methylation has an immense impact on many cellular functions including aggressiveness of a tumor and resistance against chemotherapy.
The researchers expect that this could be a way to eliminate leukemia stem cells and thereby substantially improve the prognosis of AML patients. Sincehe has also been working as an assistant physician at Heidelberg University Hospital.
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They develop novel approaches to make tumor diagnosis more
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The staff of the Cancer Information Service KID offers information about the widespread disease of cancer for patients, their Sri Lanka Mädchen Kontakt, and the general public. Combining excellent university hospitals with high-profile research at a Helmholtz Center is an important contribution to improving the chances of cancer patients.
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